Organised Files

Learn more about the evidence 

supporting sdLDL-C's clinical 

role in ASCVD

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sdldl.com is an online platform intended to be a comprehensive resource both for Healthcare Professionals and Patients regarding lipids and their role in coronary heart disease. Specifically, small-dense LDL which has been scientifically and clinically proven to provide incremental information, beyond traditional lipid testing, on an individual's risk for developing CVD. 

Online Portal for sdLDL

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On-Demand Videos

A regular schedule of webinars are recorded that feature key opinion leaders from the lipid world discussing topics that will help to improve management and outcomes in CHD.  

PPT Slides

A collection of Powerpoint slides highlighting the pathophysiology of CAD, and study data involving sdLDL in the MESA, ARIC and Framingham Offspring cohorts.  Content can be utilized for integration into any presentation.

Handouts

Provide your health system and patients with the most current information on lipids and risk of CAD.  Education and awareness are the keys to changing behaviors, which help to prevent onset of preventable disease like CAD.    

Atherogenic

Predictive

Risk Enhancer

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What is sdLDL?

Low Density Lipoprotein (LDL) particles vary, specifically as it relates to their size and density. Small-dense LDL is considered to be more atherogenic which makes it the "ugly" cholesterol that contributes greatly to the development of atherosclerosis. To learn more about sdLDL in a brief four minute video, please click the link below. 

LDL

HDL

sdLDL

Traditional lipid levels do not provide sufficient data to capture residual risk for CHD.

Testing low density lipoprotein (LDL), referred to as the "bad" cholesterol, has and continues to be the hallmark for assessing an individual's risk for developing coronary heart disease (CHD).  And is the target for clinicians when managing patients with CHD when considering therapeutic intervention. However, a percentage of individuals, as high as 50%, with ideal cholesterol, still had evidence of atherosclerosis and CV events. (source)    

 

High density lipoprotein (HDL) is sometimes referred to as the "good" cholesterol.  The primary reason for deserving the good label is its ability to absorb the bad cholesterol and transport it back to the liver, where it is broken down.  So, unlike LDL, high levels of HDL lowers the risk for heart disease and stroke. 

 

Small dense LDL is the "ugly" cholesterol among the three.  LDL has many different particle sizes, and small dense LDL is thought to be a sub-fraction of LDL that has the most atherogenic (promotes fatty acid plaques).  Because of their size, sdLDL contain less cholesterol, have higher penetration into arterial walls, longer plasma residence, and are more susceptible to oxidation.      

Helping to Enhance Risk Assessment for ASCVD